These datasets contain hundreds of frontal view X-rays and considered the largest public resource for COVID-19 image data. Softw. Imag. Inspired by our recent work38, where VGG-19 besides statistically enhanced Salp Swarm Algorithm was applied to select the best features for White Blood Cell Leukaemia classification. arXiv preprint arXiv:2003.13815 (2020). Eng. CNNs are more appropriate for large datasets. In my thesis project, I developed an image classification model to detect COVID-19 on chest X-ray medical data using deep learning models such . The combination of SA and GA showed better performances than the original SA and GA. Narayanan et al.33 proposed a fuzzy particle swarm optimization (PSO) as an FS method to enhance the classification of CT images of emphysema. & Cmert, Z. Syst. After applying this technique, the feature vector is minimized from 2000 to 459 and from 2000 to 462 for Dataset1 and Dataset 2, respectively. For diagnosing COVID-19, the RT-PCR (real-time polymerase chain reaction) is a standard diagnostic test, but, it can be considered as a time-consuming test, more so, it also suffers from false negative diagnosing4. Methods: We employed a public dataset acquired from 20 COVID-19 patients, which . Compared to59 which is one of the most recent published works on X-ray COVID-19, a combination between You Only Look Once (YOLO) which is basically a real time object detection system and DarkNet as a classifier was proposed. We can call this Task 2. They are distributed among people, bats, mice, birds, livestock, and other animals1,2. Google Scholar. (18)(19) for the second half (predator) as represented below. The first one, dataset 1 was collected by Joseph Paul Cohen and Paul Morrison and Lan Dao42, where some COVID-19 images were collected by an Italian Cardiothoracic radiologist. Furthermore, the proposed GRAY+GRAY_HE+GRAY_CLAHE image representation was evaluated on two different datasets, SARS-CoV-2 CT-Scan and New_Data_CoV2, where it was found to be superior to RGB . & Dai, Q. Discriminative clustering and feature selection for brain mri segmentation. COVID-19 image classification using deep learning: Advances, challenges and opportunities COVID-19 image classification using deep learning: Advances, challenges and opportunities Comput Biol Med. Computer Department, Damietta University, Damietta, Egypt, Electrical Engineering Department, Faculty of Engineering, Fayoum University, Fayoum, Egypt, State Key Laboratory for Information Engineering in Surveying, Mapping, and Remote Sensing, Wuhan University, Wuhan, China, Department of Applied Informatics, Vytautas Magnus University, Kaunas, Lithuania, Department of Mathematics, Faculty of Science, Zagazig University, Zagazig, Egypt, School of Computer Science and Robotics, Tomsk Polytechnic University, Tomsk, Russia, You can also search for this author in It is obvious that such a combination between deep features and a feature selection algorithm can be efficient in several image classification tasks. where CF is the parameter that controls the step size of movement for the predator. Sohail, A. S.M., Bhattacharya, P., Mudur, S.P. & Krishnamurthy, S. Classification of ultrasound medical images using distance based feature selection and fuzzy-svm. SMA is on the second place, While HGSO, SCA, and HHO came in the third to fifth place, respectively. Regarding the consuming time as in Fig. Our dataset consisting of 60 chest CT images of COVID-19 and non-COVID-19 patients was pre-processed and segmented using a hybrid watershed and fuzzy c-means algorithm. JMIR Formative Research - Classifying COVID-19 Patients From Chest X-ray Images Using Hybrid Machine Learning Techniques: Development and Evaluation Published on 28.2.2023 in Vol 7 (2023) Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/42324, first published August 31, 2022 . The model was developed using Keras library47 with Tensorflow backend48. Biocybern. In57, ResNet-50 CNN has been applied after applying horizontal flipping, random rotation, random zooming, random lighting, and random wrapping on raw images. MRFGRO: a hybrid meta-heuristic feature selection method for screening COVID-19 using deep features, Detection and analysis of COVID-19 in medical images using deep learning techniques, Cov-caldas: A new COVID-19 chest X-Ray dataset from state of Caldas-Colombia, Deep learning in veterinary medicine, an approach based on CNN to detect pulmonary abnormalities from lateral thoracic radiographs in cats, COVID-Net: a tailored deep convolutional neural network design for detection of COVID-19 cases from chest X-ray images, ANFIS-Net for automatic detection of COVID-19, A multi-scale gated multi-head attention depthwise separable CNN model for recognizing COVID-19, Validating deep learning inference during chest X-ray classification for COVID-19 screening, Densely attention mechanism based network for COVID-19 detection in chest X-rays, https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/, https://github.com/ieee8023/covid-chestxray-dataset, https://stanfordmlgroup.github.io/projects/chexnet, https://www.kaggle.com/paultimothymooney/chest-xray-pneumonia, https://www.sirm.org/en/category/articles/covid-19-database/, https://drive.google.com/file/d/1-oK-eeEgdCMCnykH364IkAK3opmqa9Rvasx/view?usp=sharing, https://doi.org/10.1016/j.irbm.2019.10.006, https://research.googleblog.com/2017/11/automl-for-large-scaleimage.html, https://doi.org/10.1016/j.engappai.2020.103662, https://www.sirm.org/category/senza-categoria/covid-19/, https://doi.org/10.1016/j.future.2020.03.055, http://creativecommons.org/licenses/by/4.0/, Skin cancer detection using ensemble of machine learning and deep learning techniques, Plastic pollution induced by the COVID-19: Environmental challenges and outlook, An Inclusive Survey on Marine Predators Algorithm: Variants andApplications, A Multi-strategy Improved Outpost and Differential Evolution Mutation Marine Predators Algorithm for Global Optimization, A light-weight convolutional Neural Network Architecture for classification of COVID-19 chest X-Ray images. Syst. A deep feature learning model for pneumonia detection applying a combination of mRMR feature selection and machine learning models. 51, 810820 (2011). where \(ni_{j}\) is the importance of node j, while \(w_{j}\) refers to the weighted number of samples reaches the node j, also \(C_{j}\) determines the impurity value of node j. left(j) and right(j) are the child nodes from the left split and the right split on node j, respectively. In this paper, we propose an improved hybrid classification approach for COVID-19 images by combining the strengths of CNNs (using a powerful architecture called Inception) to extract features and . Fractional-order calculus (FC) gains the interest of many researchers in different fields not only in the modeling sectors but also in developing the optimization algorithms. Marine memory: This is the main feature of the marine predators and it helps in catching the optimal solution very fast and avoid local solutions. where r is the run numbers. and JavaScript. The 30-volume set, comprising the LNCS books 12346 until 12375, constitutes the refereed proceedings of the 16th European Conference on Computer Vision, ECCV 2020, which was planned to be held in Glasgow, UK, during August 23-28, 2020. For the exploration stage, the weibull distribution has been applied rather than Brownian to bost the performance of the predator in stage 2 and the prey velocity in stage 1 based on the following formula: Where k, and \(\zeta\) are the scale and shape parameters. In this paper, we apply a convolutional neural network (CNN) to extract features from COVID-19 X-Ray images. Nguyen, L.D., Lin, D., Lin, Z. In this paper, different Conv. Comput. For example, as our input image has the shape \(224 \times 224 \times 3\), Nasnet26 produces 487 K features, Resnet25 and Xception29 produce about 100 K features and Mobilenet27 produces 50 K features, while FO-MPA produces 130 and 86 features for both dataset1 and dataset 2, respectively. & SHAH, S. S.H. The diagnostic evaluation of convolutional neural network (cnn) for the assessment of chest x-ray of patients infected with covid-19. It also contributes to minimizing resource consumption which consequently, reduces the processing time. We build the first Classification model using VGG16 Transfer leaning framework and second model using Deep Learning Technique Convolutional Neural Network CNN to classify and diagnose the disease and we able to achieve the best accuracy in both the model. Toaar, M., Ergen, B. Lett. The evaluation outcomes demonstrate that ABC enhanced precision, and also it reduced the size of the features. By submitting a comment you agree to abide by our Terms and Community Guidelines. It is important to detect positive cases early to prevent further spread of the outbreak. FCM reinforces the ANFIS classification learning phase based on the features of COVID-19 patients. Cancer 48, 441446 (2012). The Marine Predators Algorithm (MPA)is a recently developed meta-heuristic algorithm that emulates the relation among the prey and predator in nature37. (iii) To implement machine learning classifiers for classification of COVID and non-COVID image classes. 6, right), our approach still provides an overall accuracy of 99.68%, putting it first with a slight advantage over MobileNet (99.67 %). HIGHLIGHTS who: Qinghua Xie and colleagues from the Te Afliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China have published the Article: Automatic Segmentation and Classification for Antinuclear Antibody Images Based on Deep Learning, in the Journal: Computational Intelligence and Neuroscience of 14/08/2022 what: Terefore, the authors . Nevertheless, a common mistake in COVID-19 dataset fusion, mainly on classification tasks, is that by mixing many datasets of COVID-19 and using as Control images another dataset, there will be . You are using a browser version with limited support for CSS. He, K., Zhang, X., Ren, S. & Sun, J. Feature selection using flower pollination optimization to diagnose lung cancer from ct images. Table4 show classification accuracy of FO-MPA compared to other feature selection algorithms, where the best, mean, and STD for classification accuracy were calculated for each one, besides time consumption and the number of selected features (SF). Remainder sections are organized as follows: Material and methods sectionpresents the methodology and the techniques used in this work including model structure and description. In such a case, in order to get the advantage of the power of CNN and also, transfer learning can be applied to minimize the computational costs21,22. Coronavirus Disease (COVID-19): A primer for emergency physicians (2020) Summer Chavez et al. J. However, the proposed IMF approach achieved the best results among the compared algorithms in least time. Dual feature selection and rebalancing strategy using metaheuristic optimization algorithms in x-ray image datasets. In addition, the good results achieved by the FO-MPA against other algorithms can be seen as an advantage of FO-MPA, where a balancing between exploration and exploitation stages and escaping from local optima were achieved. The survey asked participants to broadly classify the findings of each chest CT into one of the four RSNA COVID-19 imaging categories, then select which imaging features led to their categorization. ), such as \(5\times 5\), \(3 \times 3\), \(1 \times 1\). Kong, Y., Deng, Y. Image segmentation is a necessary image processing task that applied to discriminate region of interests (ROIs) from the area of outsides. & Carlsson, S. Cnn features off-the-shelf: an astounding baseline for recognition. Automated detection of alzheimers disease using brain mri imagesa study with various feature extraction techniques. Future Gener. The results are the best achieved on these datasets when compared to a set of recent feature selection algorithms. Fractional Differential Equations: An Introduction to Fractional Derivatives, Fdifferential Equations, to Methods of their Solution and Some of Their Applications Vol. They employed partial differential equations for extracting texture features of medical images. Image Classification With ResNet50 Convolution Neural Network (CNN) on Covid-19 Radiography | by Emmanuella Anggi | The Startup | Medium 500 Apologies, but something went wrong on our end.. Also, because COVID-19 is a virus, distinguish COVID-19 from common viral . Both the model uses Lungs CT Scan images to classify the covid-19. A.A.E. Harikumar et al.18 proposed an FS method based on wavelets to classify normality or abnormality of different types of medical images, such as CT, MRI, ultrasound, and mammographic images. In transfer learning, a CNN which was previously trained on a large & diverse image dataset can be applied to perform a specific classification task by23. Table3 shows the numerical results of the feature selection phase for both datasets. The family of coronaviruses is considered serious pathogens for people because they infect respiratory, hepatic, gastrointestinal, and neurologic diseases. In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 19 (2015). (8) at \(T = 1\), the expression of Eq. Since its structure consists of some parallel paths, all the paths use padding of 1 pixel to preserve the same height & width for the inputs and the outputs. and M.A.A.A. AMERICAN JOURNAL OF EMERGENCY MEDICINE COVID-19: Facemask use prevalence in international airports in Asia, Europe and the Americas, March 2020 Med. Early diagnosis, timely treatment, and proper confinement of the infected patients are some possible ways to control the spreading of . A survey on deep learning in medical image analysis. The given Kaggle dataset consists of chest CT scan images of patients suffering from the novel COVID-19, other pulmonary disorders, and those of healthy patients. Sahlol, A.T., Yousri, D., Ewees, A.A. et al. In 2019 26th National and 4th International Iranian Conference on Biomedical Engineering (ICBME), 194198 (IEEE, 2019). For this motivation, we utilize the FC concept with the MPA algorithm to boost the second step of the standard version of the algorithm. To segment brain tissues from MRI images, Kong et al.17 proposed an FS method using two methods, called a discriminative clustering method and the information theoretic discriminative segmentation. Sci. Deep-learning artificial intelligent (AI) methods have the potential to help improve diagnostic efficiency and accuracy for reading portable CXRs. In Smart Intelligent Computing and Applications, 305313 (Springer, 2019). Purpose The study aimed at developing an AI . Then, using an enhanced version of Marine Predators Algorithm to select only relevant features. Hence, the FC memory is applied during updating the prey locating in the second step of the algorithm to enhance the exploitation stage. (23), the general formulation for the solutions of FO-MPA based on FC memory perspective can be written as follows: After checking the previous formula, it can be detected that the motion of the prey becomes based on some terms from the previous solutions with a length of (m), as depicted in Fig. }\delta (1-\delta )(2-\delta )(3-\delta ) U_{i}(t-3) + P.R\bigotimes S_i. (20), \(FAD=0.2\), and W is a binary solution (0 or 1) that corresponded to random solutions. 2 (left). Whereas, FO-MPA, MPA, HGSO, and WOA showed similar STD results. While the second dataset, dataset 2 was collected by a team of researchers from Qatar University in Qatar and the University of Dhaka in Bangladesh along with collaborators from Pakistan and Malaysia medical doctors44. Recently, a combination between the fractional calculus tool and the meta-heuristics opens new doors in providing robust and reliable variants41. So, based on this motivation, we apply MPA as a feature selector from deep features that produced from CNN (largely redundant), which, accordingly minimize capacity and resources consumption and can improve the classification of COVID-19 X-ray images. Provided by the Springer Nature SharedIt content-sharing initiative, Environmental Science and Pollution Research (2023), Archives of Computational Methods in Engineering (2023), Arabian Journal for Science and Engineering (2023). Medical imaging techniques are very important for diagnosing diseases. and pool layers, three fully connected layers, the last one performs classification. Moreover, we design a weighted supervised loss that assigns higher weight for . They applied a fuzzy decision tree classifier, and they found that fuzzy PSO improved the classification accuracy. There are three main parameters for pooling, Filter size, Stride, and Max pool. Simonyan, K. & Zisserman, A. \(r_1\) and \(r_2\) are the random index of the prey. Li, J. et al. Multimedia Tools Appl. Nature 503, 535538 (2013). Sci. Table2 shows some samples from two datasets. Using the best performing fine-tuned VGG-16 DTL model, tests were carried out on 470 unlabeled image dataset, which was not used in the model training and validation processes. Zhang, N., Ruan, S., Lebonvallet, S., Liao, Q. Li, S., Chen, H., Wang, M., Heidari, A. Comput. Figure5 illustrates the convergence curves for FO-MPA and other algorithms in both datasets. Coronavirus disease (Covid-19) is an infectious disease that attacks the respiratory area caused by the severe acute . One from the well-know definitions of FC is the Grunwald-Letnikov (GL), which can be mathematically formulated as below40: where \(D^{\delta }(U(t))\) refers to the GL fractional derivative of order \(\delta\). For fair comparison, each algorithms was performed (run) 25 times to produce statistically stable results.The results are listed in Tables3 and4. (3), the importance of each feature is then calculated. Its structure is designed based on experts' knowledge and real medical process. The symbol \(r\in [0,1]\) represents a random number. We do not present a usable clinical tool for COVID-19 diagnosis, but offer a new, efficient approach to optimize deep learning-based architectures for medical image classification purposes. After feature extraction, we applied FO-MPA to select the most significant features. Although outbreaks of SARS and MERS had confirmed human to human transmission3, they had not the same spread speed and infection power of the new coronavirus (COVID-19). However, the modern name is tenggiling.In Javanese it is terenggiling; and in the Philippine languages, it is goling, tanggiling, or balintong (with the same meaning).. Mutation: A mutation refers to a single change in a virus's genome (genetic code).Mutations happen frequently, but only sometimes change the characteristics of the virus. They compared the BA to PSO, and the comparison outcomes showed that BA had better performance. (22) can be written as follows: By using the discrete form of GL definition of Eq. 78, 2091320933 (2019). Meanwhile, the prey moves effectively based on its memory for the previous events to catch its food, as presented in Eq. \(Fit_i\) denotes a fitness function value. Cite this article. Accordingly, the prey position is upgraded based the following equations. This dataset consists of 219 COVID-19 positive images and 1341 negative COVID-19 images. In addition, up to our knowledge, MPA has not applied to any real applications yet. Syst. arXiv preprint arXiv:2003.13145 (2020). Softw. COVID 19 X-ray image classification. Both datasets shared some characteristics regarding the collecting sources. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. 121, 103792 (2020). arXiv preprint arXiv:1704.04861 (2017). It noted that all produced feature vectors by CNNs used in this paper are at least bigger by more than 300 times compared to that produced by FO-MPA in terms of the size of the featureset. Going deeper with convolutions. The code of the proposed approach is also available via the following link [https://drive.google.com/file/d/1-oK-eeEgdCMCnykH364IkAK3opmqa9Rvasx/view?usp=sharing]. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. In the last two decades, two famous types of coronaviruses SARS-CoV and MERS-CoV had been reported in 2003 and 2012, in China, and Saudi Arabia, respectively3. In14, the authors proposed an FS method based on a convolutional neural network (CNN) to detect pneumonia from lung X-ray images. The largest features were selected by SMA and SGA, respectively. The Softmax activation function is used for this purpose because the output should be binary (positive COVID-19 negative COVID-19). COVID-19-X-Ray-Classification Utilizing Deep Learning to detect COVID-19 and Viral Pneumonia from x-ray images Research Publication: https://dl.acm.org/doi/10.1145/3431804 Datasets used: COVID-19 Radiography Database COVID-19 10000 Images Related Research Papers: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187882/ The results are the best achieved compared to other CNN architectures and all published works in the same datasets. Afzali, A., Mofrad, F.B. chest X-ray images into three classes of COVID-19, normal chest X-ray and other lung diseases. FP (false positives) are the positive COVID-19 images that were incorrectly labeled as negative COVID-19, while FN (false negatives) are the negative COVID-19 images that were mislabeled as positive COVID-19 images. The test accuracy obtained for the model was 98%. (4). Bibliographic details on CECT: Controllable Ensemble CNN and Transformer for COVID-19 image classification by capturing both local and global image features. The results of max measure (as in Eq. In this experiment, the selected features by FO-MPA were classified using KNN. Imaging 35, 144157 (2015). Mirjalili, S. & Lewis, A. Szegedy, C. et al. \(\bigotimes\) indicates the process of element-wise multiplications. It also shows that FO-MPA can select the smallest subset of features, which reflects positively on performance. Bukhari, S. U.K., Bukhari, S. S.K., Syed, A. This paper reviews the recent progress of deep learning in COVID-19 images applications from five aspects; Firstly, 33 COVID-19 datasets and data enhancement methods are introduced; Secondly, COVID-19 classification methods . Dhanachandra, N. & Chanu, Y. J. Inspired by this concept, Faramarzi et al.37 developed the MPA algorithm by considering both of a predator a prey as solutions. The conference was held virtually due to the COVID-19 pandemic. & Cmert, Z. In our example the possible classifications are covid, normal and pneumonia. Harikumar, R. & Vinoth Kumar, B. Robertas Damasevicius. Initialize solutions for the prey and predator. One of the main disadvantages of our approach is that its built basically within two different environments. 35, 1831 (2017). 25, 3340 (2015). <span> <h5>Background</h5> <p>The COVID19 pandemic has precipitated global apprehensions about increased fatalities and raised concerns about gaps in healthcare . kharrat and Mahmoud32proposed an FS method based on a hybrid of Simulated Annealing (SA) and GA to classify brain tumors using MRI. They applied the SVM classifier for new MRI images to segment brain tumors, automatically. The whole dataset contains around 200 COVID-19 positive images and 1675 negative COVID19 images. and A.A.E. Propose a novel robust optimizer called Fractional-order Marine Predators Algorithm (FO-MPA) to select efficiently the huge feature vector produced from the CNN. 10, 10331039 (2020). We are hiring! ISSN 2045-2322 (online). Sahlol, A. T., Kollmannsberger, P. & Ewees, A. In COVID19 triage, DB-YNet is a promising tool to assist physicians in the early identification of COVID19 infected patients for quick clinical interventions. Figure3 illustrates the structure of the proposed IMF approach. Accordingly, that reflects on efficient usage of memory, and less resource consumption. COVID-19 is the most transmissible disease, caused by the SARS-CoV-2 virus that severely infects the lungs and the upper respiratory tract of the human body.This virus badly affected the lives and wellness of millions of people worldwide and spread widely. Health Inf. (9) as follows. Metric learning Metric learning can create a space in which image features within the. Also, other recent published works39, who combined a CNN architecture with Weighted Symmetric Uncertainty (WSU) to select optimal features for traffic classification. Apostolopoulos, I. D. & Mpesiana, T. A. Covid-19: automatic detection from x-ray images utilizing transfer learning with convolutional neural networks. Chollet, F. Xception: Deep learning with depthwise separable convolutions. 42, 6088 (2017). In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 770778 (2016). Lambin, P. et al. Imaging 29, 106119 (2009). This study presents an investigation on 16 pretrained CNNs for classification of COVID-19 using a large public database of CT scans collected from COVID-19 patients and non-COVID-19 subjects. Civit-Masot et al. Extensive evaluation experiments had been carried out with a collection of two public X-ray images datasets. My education and internships have equipped me with strong technical skills in Python, deep learning models, machine learning classification, text classification, and more. Cauchemez, S. et al. Chexnet: Radiologist-level pneumonia detection on chest x-rays with deep learning. It is also noted that both datasets contain a small number of positive COVID-19 images, and up to our knowledge, there is no other sufficient available published dataset for COVID-19. ADS 41, 923 (2019). According to the promising results of the proposed model, that combines CNN as a feature extractor and FO-MPA as a feature selector could be useful and might be successful in being applied in other image classification tasks. Experimental results have shown that the proposed Fuzzy Gabor-CNN algorithm attains highest accuracy, Precision, Recall and F1-score when compared to existing feature extraction and classification techniques. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Multimedia Tools Appl. Stage 1: After the initialization, the exploration phase is implemented to discover the search space. Robustness-driven feature selection in classification of fibrotic interstitial lung disease patterns in computed tomography using 3d texture features. a cough chills difficulty breathing tiredness body aches headaches a new loss of taste or smell a sore throat nausea and vomiting diarrhea Not everyone with COVID-19 develops all of these. Slider with three articles shown per slide. Ge, X.-Y. Google Research, https://research.googleblog.com/2017/11/automl-for-large-scaleimage.html, Blog (2017). Mirjalili, S., Mirjalili, S. M. & Lewis, A. Grey wolf optimizer. They concluded that the hybrid method outperformed original fuzzy c-means, and it had less sensitive to noises. A NOVEL COMPARATIVE STUDY FOR AUTOMATIC THREE-CLASS AND FOUR-CLASS COVID-19 CLASSIFICATION ON X-RAY IMAGES USING DEEP LEARNING: Authors: Yaar, H. Ceylan, M. Keywords: Convolutional neural networks Covid-19 Deep learning Densenet201 Inceptionv3 Local binary pattern Local entropy X-ray chest classification Xception: Issue Date: 2022: Publisher: 152, 113377 (2020). Whereas, the worst algorithm was BPSO. Also, in58 a new CNN architecture called EfficientNet was proposed, where more blocks were added on top of the model after applying normalization of images pixels intensity to the range (0 to 1). where \(R_L\) has random numbers that follow Lvy distribution. Furthermore, using few hundreds of images to build then train Inception is considered challenging because deep neural networks need large images numbers to work efficiently and produce efficient features. Currently, a new coronavirus, called COVID-19, has spread to many countries, with over two million infected people or so-called confirmed cases.